Benign Breast Lesions That Mimic Cancer: Determining Radiologic-Pathologic Concordance

Julia Mario, BA; Shambhavi Venkataraman, MD; Vandana Dialani, MD; Priscilla J. Slanetz MD, MPH


Appl Radiol. 2015;44(9):28-32. 

In This Article

Spindle Cell Lesions

Spindle cell lesions comprise a wide spectrum of proliferative diseases, some of which are benign. Many spindle cell lesions result from overgrowth of fibroblasts and myofibroblasts, which are a normal part of the lobular mammary stroma.[28,29] Benign proliferations of fibro- and myofibroblasts have a range of clinical characteristics and include pseudoangiomatous stromal hyperplasia (PASH), myofibroblastoma, and fibromatosis. It is difficult to discern between the various types of spindle cell lesions both on imaging and on histopathology from core biopsy. Obtaining sufficient tissue samples during biopsy is critical in making an accurate diagnosis on needle biopsy and obviating the need for subsequent surgical excision.