Treatments for Delusional Disorder

Mike Skelton; Waqqas Ahmad Khokhar; Simon P. Thacker


Schizophr Bull. 2015;41(5) 

In This Article

Main Results

Only 1 randomized trial met our inclusion criteria, despite our initial search yielding 141 citations. This was a small study, with 17 people completing a trial comparing CBT to an attention placebo (supportive psychotherapy) for people with delusional disorder. Most participants were already taking medication and this was continued during the trial. We were not able to include any randomized trials on medications of any type due to poor data reporting, which left us with no usable data for these trials. For the included study, usable data were limited, risk of bias varied, and the numbers involved were small, making interpretation of data difficult. In particular there were no data on outcomes such as global state and behaviour, nor any information on possible adverse effects.

A positive effect for CBT was found for social self-esteem using the Social Self-Esteem Inventory (1 RCT, n = 17, MD 30.5, CI 7.51 to 53.49, very low quality evidence, Table 1), however this is only a measure of self-worth in social situations and may thus not be well correlated to social function. More people left the study early if they were in the supportive psychotherapy group with 6/12 leaving early compared to 2/12 from the CBT group, but the difference was not significant (1 RCT, n = 17, RR 0.33, CI 0.08 to 1.33, moderate quality evidence). For mental state outcomes the results were skewed making interpretation difficult, especially given the small sample.