Gut Microbiota in Hypertension

Pedro A. Jose; Dominic Raj

Disclosures

Curr Opin Nephrol Hypertens. 2015;24(5):403-409. 

In This Article

Conclusion

In summary, microbiota can be controlled by many factors including diet, physical activity, genetics, and epigenetics. The influence of gut microbiota on the host may be partially explained by the generation of SCFAs, including the beneficial SCFAs (acetate, butyrate, and propionate) and the nonbeneficial lactate. These SCFAs acting on cell surface receptors, including GPR43, GPR41, and Olfr78, regulate blood pressure (Fig. 1). Gut microbiota can also influence the state of immunity and inflammation, cell metabolism, and proliferation that may eventually affect blood pressure.

Figure 1.

Microbiota can be controlled by many factors including diet, physical activity, genetics, and epigenetics. The influence of gut microbiota on the host may be partially explained by the generation of short-chain fatty acids, including the beneficial acetate, butyrate and propionate, and nonbeneficial lactate. These short-chain fatty acids acting on cell surface receptors, including GPR43, GPR41, and Olfr78, regulate blood pressure. GPR41 and Olfr78 counter-regulate each other.

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