Combination Therapy of Varenicline With Nicotine Replacement Therapy Is Better Than Varenicline Alone

A Systematic Review and Meta-analysis of Randomized Controlled Trials

Ping-Hsun Chang; Chien-Hsieh Chiang; Wei-Che Ho; Pei-Zu Wu; Jaw-Shiun Tsai; Fei-Ran Guo


BMC Public Health. 2015;15(689) 

In This Article


The combination therapy of varenicline with NRT is more effective than varenicline alone in smoking cessation. This effect is more evident if pre-cessation treatment of nicotine patch is administrated. The adverse events of combination therapy are comparable to varenicline mono-therapy with the exception of skin reactions. Larger RCTs are needed to make more robust conclusions.