Combination Therapy of Varenicline With Nicotine Replacement Therapy Is Better Than Varenicline Alone

A Systematic Review and Meta-analysis of Randomized Controlled Trials

Ping-Hsun Chang; Chien-Hsieh Chiang; Wei-Che Ho; Pei-Zu Wu; Jaw-Shiun Tsai; Fei-Ran Guo

Disclosures

BMC Public Health. 2015;15(689) 

In This Article

Conclusions

The combination therapy of varenicline with NRT is more effective than varenicline alone in smoking cessation. This effect is more evident if pre-cessation treatment of nicotine patch is administrated. The adverse events of combination therapy are comparable to varenicline mono-therapy with the exception of skin reactions. Larger RCTs are needed to make more robust conclusions.

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