Drug Interaction in the Elderly: Beware the Antibiotics

Douglas S. Paauw, MD


August 03, 2015

Why Is This Elderly Woman Feeling Poorly?

An 83-year-old woman with type 2 diabetes mellitus is brought in for evaluation for altered mental status. She has been feeling poorly for the past 2 weeks, and has been undergoing treatment for presumed Helicobacter pylori gastritis and a urinary tract infection. Her current medications are bismuth subsalicylate, glyburide, sitagliptin, omeprazole, amoxicillin, trimethoprim/sulfamethoxazole (TMP/SMX), and lisinopril.

Laboratory test results include the following:

  • Sodium: 132 mEq/mL

  • Potassium: 5 mEq/mL

  • Chloride: 100 mEq/mL

  • Glucose: 30 mg/dL


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