Arterial Blood Pressure Targets in Septic Shock

Is It Time to Move to an Individualized Approach?

Thiago Domingos Corrêa; Stephan Matthias Jakob; Jukka Takala


Crit Care. 2015;19(1) 

In This Article


Xu and colleagues evaluated the impact of increasing mean arterial blood pressure levels through norepinephrine administration on systemic hemodynamics, tissue perfusion, and sublingual microcirculation of septic shock patients with chronic hypertension. The authors concluded that, although increasing arterial blood pressure improved sublingual microcirculation parameters, no concomitant improvement in systemic tissue perfusion indicators was found. Here, we discuss why resuscitation targets may need to be individualized, taking into account the patient's baseline condition, and present directions for future research in this field.