The Role of Sex in Uveitis and Ocular Inflammation

Ian Y. L. Yeung, MD; Nicholas A. Popp, BS; Chi-Chao Chan, MD


Int Ophthalmol Clin. 2015;55(3):111-131. 

In This Article


Male predominant autoimmune diseases, such as BD usually manifest clinically before the age of 50 and are characterized by acute inflammation and a Th1 response. HLA-B27-associated anterior uveitis in men is an example of this. Female predominant autoimmunity, such as RA and SLE tends to present later in life and occur likely via Th2 and autoantibody-related mechanisms. Recognition of the sex difference in autoimmunity including uveitis should allow new preventative and therapeutic strategies for patients in the future.[4]