Yellow Fever Vaccine Booster Doses: Recommendations of the Advisory Committee on Immunization Practices, 2015

J. Erin Staples, MD; Joseph A. Bocchini Jr., MD; Lorry Rubin, MD; Marc Fischer, MD


Morbidity and Mortality Weekly Report. 2015;64(23):647-650. 

In This Article

Rationale for Yellow Fever Vaccine Booster Dose Recommendations

The GRADE evaluation found that there are few vaccine failures documented after a primary dose of yellow fever vaccine, most (92%) primary vaccine recipients maintain detectable levels of neutralizing antibodies ≥10 years post-vaccination, and few serious adverse events have been reported after a booster dose of yellow fever vaccine.[3] Based on the available data, ACIP voted to no longer recommend booster dose of yellow fever vaccine for most travelers, because a single dose of yellow fever vaccine provides long-lasting protection (Box). However, additional doses of yellow fever vaccine are recommended for certain populations (i.e., pregnant women, hematopoietic stem cell transplant recipients, and HIV-infected persons) who might not have as robust or sustained immune response to yellow fever vaccine compared with other recipients. Furthermore, additional doses may be given to certain groups believed to be at increased risk for yellow fever disease either because of their location and duration of travel or because of more consistent exposure to virulent virus (i.e., laboratory workers). ACIP meeting minutes are available at