Liver Fat Accumulation in Response to Overfeeding With a High-fat Diet

A Comparison Between South Asian and Caucasian Men

Siti N. Wulan; Vera B. Schrauwen-Hinderling; Klaas R. Westerterp; Guy Plasqui


Nutr Metab. 2015;12(18) 

In This Article


In summary, when groups are matched for body fat percentage, no differences in liver fat were found at baseline between South Asians and Caucasians and both groups showed a similar increase in hepatic lipid content in response to a hypercaloric, high-fat diet. This suggests that differences between ethnicities that were reported so far may (at least partially) be ascribed to differences in body fat percentage.

Future studies to compare the response of different ethnicities to dietary intervention may be approached by matching body fat percentage within a closer range, by including only lean or only overweight subjects, to avoid large inter-individual variation.