Vibration-controlled Transient Elastography

A Practical Approach to the Noninvasive Assessment of Liver Fibrosis

Elliot B. Tapper; Nezam H. Afdhal


Curr Opin Gastroenterol. 2015;31(3):192-198. 

In This Article

Vibration-controlled Transient Elastography in Other Liver Diseases

The role of VCTE in autoimmune hepatitis remains unclear given the persistent need for the histological assessment of inflammatory activity to guide therapy.[53] Data are insufficient to make recommendations for hemochromatosis.[54] A recent study of 77 French patients with hemochromatosis (homozygous for the C282Y HFE gene mutation) yielded some preliminary data that suggests VCTE is likely useful in this population.[55] A cutoff of 13.9 kPa provides 100% specificity and 64% sensitivity for F3-F4 fibrosis. Finally, and perhaps as expected, experience with VCTE in rare metabolic diseases such as Wilson disease or Alpha-1 antitrypsin is extremely limited.[56]