Digoxin Use in Modern Medicine

Shan Chen, PharmD Candidate; Troy Khusial, PharmD Candidate; Dipen Patel, PharmD Candidate; Satinder Singh, PharmD Candidate; Tatyana Yakubova, PharmD Candidate; Amy Wang, PharmD, BCPS, MBA; Timothy Nguyen, PharmD, BCPS, CCP, FASCP


US Pharmacist. 2015;40(2):44-48. 

In This Article


The use of digoxin has been limited because the agent has a narrow therapeutic index and requires close monitoring. Digoxin can lead to many AEs and has multiple drug interactions. Despite its limitations, digoxin still has a place in therapy for HF, AF, and numerous off-label uses. It is considered adjunctive therapy, rather than first-line therapy.