Digoxin Use in Modern Medicine

Shan Chen, PharmD Candidate; Troy Khusial, PharmD Candidate; Dipen Patel, PharmD Candidate; Satinder Singh, PharmD Candidate; Tatyana Yakubova, PharmD Candidate; Amy Wang, PharmD, BCPS, MBA; Timothy Nguyen, PharmD, BCPS, CCP, FASCP


US Pharmacist. 2015;40(2):44-48. 

In This Article

Digoxin Toxicity

Owing to its narrow therapeutic index, digoxin toxicity is quite common. Clinical manifestations of acute digoxin toxicity include arrhythmias, anorexia, confusion, and hyperkalemia.[3] Chronic digoxin toxicity presents similarly, with the addition of halos, green-yellow vision, blindness, lethargy, and fatigue (Table 3).[3] Digoxinspecific antibody (DigiFab) is used to treat digoxin poisoning. DigiFab binds to free digoxin, forming a complex that is excreted renally, thereby reducing serum digoxin concentrations.[3]