Updated Recommendations for the Use of Typhoid Vaccine — Advisory Committee on Immunization Practices, United States, 2015

Brendan R. Jackson, MD; Shahed Iqbal, PhD; Barbara Mahon, MD


Morbidity and Mortality Weekly Report. 2015;64(11):305-308. 

In This Article

Choice of Vaccine

Parenteral Vi polysaccharide and oral Ty21a are both acceptable forms of typhoid vaccine.

The Vi polysaccharide vaccine is administered as a single injection and is approved for adults and children aged ≥2 years. The oral Ty21a vaccine is administered in 4 doses on alternating days over 1 week and is approved for adults and children aged ≥6 years. Immunocompromised persons should not use Ty21a because it is a live-attenuated vaccine. Because antibacterial drugs might be active against the vaccine strain and reduce immunogenicity, the Ty21a vaccine should not be administered to persons taking these medications.