New Frontiers in Urethral Reconstruction

Injectables and Alternative Grafts

Alex J. Vanni


Transl Androl Urol. 2015;4(1):84-91. 

In This Article


Anti-fibrotic injectables are an intriguing attempt at improving endoscopic stricture management. While preliminary data is encouraging, more rigid outcomes measures will be critical to properly evaluate the role these adjuncts play with regards to traditional treatment. Well-controlled clinical trials with long-term follow-up are needed to determine the optimal antifibrotic drug and technical approach for these novel agents.

Urethral reconstruction continues to be an evolving specialty due to the uniform difficulty in treating complex urethral strictures. The reconstructive urologist needs to be comfortable with a number of grafts in order to best treat each individual patient's condition. Tissue engineered grafts continue to show promise, but further study is needed to improve upon existing platforms.