Caffeine and Menopausal Symptoms

What Is the Association?

Stephanie S. Faubion, MD; Richa Sood, MD; Jacqueline M. Thielen, MD; Lynne T. Shuster, MD


Menopause. 2015;22(2):155-158. 

In This Article


A total of 2,507 MHQs were completed during the study period. We also eliminated those questionnaires that had incomplete data and those completed by individuals seen at subsequent visits (in other words, we only kept the first questionnaire if a woman completed the same form when returning for later visits). Furthermore, only women aged 40 years or older were included in the analysis to focus on the menopausal transition. The MHQs from 1,806 women were ultimately included in the study. Of these 1,806 women (mean age, 53.7 y; range, 40-82 y), 84% reported consumption of caffeine and 7% were current smokers. Most women (69%) reported being postmenopausal. Menopause status was similar among caffeine users and nonusers. The prevalence of cigarette smoking was higher in those who consumed caffeine than in those who did not ( Table 1 ).

Compared with those who did not consume caffeine, caffeine users had higher mean (SD) vasomotor symptom bother scores (2.30 [0.91] vs 2.15 [0.94], P = 0.011). After adjustment for smoking and menopause status, caffeine use remained significantly associated with increased vasomotor symptom bother (P=0.027).

There were no significant associations between caffeine use and symptom domains other than the neurocognitive domain ( Table 2 ). For this domain, no significant differences were found on univariable analyses. However, on multivariable analyses, after adjustment for menopause status and cigarette smoking, the use of caffeine was associated with decreased neurocognitive symptom bother (P = 0.035). There was some suggestion of a caffeine–menopause status interaction (P = 0.058), implying that the association between caffeine use and neurocognitive symptoms might differ between those who were menopausal and those who were not. On further analysis, caffeine use was found to be associated with lower neurocognitive symptom bother in premenopausal women who were caffeine users compared with nonusers (2.00 [0.61] vs 2.19 [0.68], P = 0.030), but no difference was found in postmenopausal women (1.87 [0.62] vs 1.88 [0.61], P=0.77).