Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes

Annick V. Hartstra; Kristien E.C. Bouter; Fredrik Bäckhed; Max Nieuwdorp


Diabetes Care. 2015;38(1):159-165. 

In This Article


The determination of the intestinal microbiome in obesity and T2DM has led to an exponential increase of scientific research in this area. In this review, we tried to cover several topics in order to provide clinically relevant insight. A multitude of studies has revealed various potential mechanisms, ranging from endocrine and metabolic pathways to mechanisms on a cellular and genetic level. Our understanding of environmental factors affecting the microbiome, such as our diet, repetitive infections, and the use of antibiotics, is improving and will hopefully contribute to finding a solution for the global obesity epidemic.