Plasma Triglycerides Predict Ten-years All-cause Mortality in Outpatients With Type 2 Diabetes Mellitus

A Longitudinal Observational Study

Maria-Agata Miselli; Edoardo Dalla Nora; Angelina Passaro; Franco Tomasi; Giovanni Zuliani


Cardiovasc Diabetol. 2014;13(135) 

In This Article

Abstract and Introduction


Background Cardiovascular disease (CVD) is the leading cause of death in type 2 diabetes mellitus (T2DM). American Diabetes Association standards of care set a series of targets recommended for the CVD prevention: blood pressure, LDL and HDL cholesterol (LDL-C and HDL-C), triglycerides and HbA1c goals. The aim of this study was to evaluate cardiovascular risk factors in a T2DM outpatient population in order to estimate their specific clinical value in predicting long-term overall mortality.

Methods Our study population was composed of 1917 T2DM outpatients attending the hospital-based Diabetes Clinic of Ferrara for a mean follow-up period of 10 years; recorded information included personal, clinical and biochemical data, and pharmacological treatment.

Results A Cox proportional hazard analysis was performed, pointing out as age (HR:1.08; IC95%: 1.06-1.11), sex (males: HR:1.97; IC95%: 1.26–3.07), mean triglycerides levels during follow-up (III vs I tertile: HR:1.87; IC95%: 1.12–3.12) and lipid-lowering treatment (HR:0.56; IC95%: 0.35–0.90) were significantly associated with all-cause mortality, independent of confounding factors such as mean values of LDL-C, HDL-C, HbA1c, blood pressure, BMI, fasting glucose, and antihypertensive and antidiabetic treatment.

Conclusions This finding suggests that more attention should be given to the management of cardiovascular risk in type 2 diabetic patients with high triglycerides levels.