Top 10 Practice Changers in Gastroenterology: 2014

David A. Johnson, MD


December 09, 2014

In This Article

Inflammatory Bowel Disease Is Associated With an Increased Risk of Melanoma: A Systematic Review and Meta-analysis

Singh S, Nagpal SJ, Murad MH, et al
Clin Gastroenterol Hepatol. 2014;12:210-218

How Big Is the Risk?

To evaluate the overall risk for melanoma in patients with IBD, investigators conducted a meta-analysis of 12 cohort studies comprising 172,837 patients. Compared with the general population, the incidence of melanoma was 37% higher in patients with IBD, 51% higher in patients with Crohn disease, and 23% higher in patients with ulcerative colitis. Although more recently, the focus in melanoma and nonmelanoma skin cancers has been on patients receiving thiopurines or biologic agents, on the basis of this meta-analysis, IBD is associated with an increased risk for melanoma independent of therapy.

Clinicians should counsel these patients on their risk for melanoma and consider periodic dermatologic evaluations, especially for patients on immunosuppressants or biologic therapies.



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