The present study provides insights into the role ultrasensitive serum PSA measurements plays in determining who will develop BCR after radical prostatectomy and, such as, be candidates for secondary treatment. The kinetics of postoperative PSA decline may allow better stratification of patients who would benefit from immediate radiation therapy.
PSM: Positive surgical margins; RP: Radical prostatectomy; PSA: Prostate-specific antigen; BCR: Biochemical recurrence; AUC: Area under the curve; HR: Hazard ratio; ROC: Receiver operating characteristic curve.
The authors declare that they have no competing interests.
SV designed the study, collected and analyzed data, wrote and drafted the manuscript, LJ was involved in revising the manuscript critically for important intellectual content, KD collected the follow-up data and contributed to conception and design, MS drafted the manuscript, PD made the contribution to acquisition of data, MB made substantial contributions All authors read and approved the manuscript.
Supported by the project (Ministry of Health, Czech Republic) for conceptual development of research organization 00064203 (University Hospital Motol, Prague, Czech Republic).
BMC Urol. 2014;14(79) © 2014 BioMed Central, Ltd.