Association between the anatomical degree of LSS and the clinical findings is a complex one. Our findings indicate that advanced degenerative hypertrophy may potentially be a protective mechanism that causes relief of patient symptoms. Follow-up studies are needed to confirm if symptoms of patients with LSS may improve despite the progression of the anatomical degree of central LSS.
The authors report no declarations of interests.
Guarantors of integrity of entire study, OA, HK; study concepts/study design or data acquisition or data analysis/interpretation, all authors; manuscript drafting or manuscript revision for important intellectual content, all authors; approval of final version of submitted manuscript, all authors; literature research, PK, PS, VL, TA; clinical studies, TA, SS, TS; statistical analysis, PK, VL, PS; and manuscript editing, all authors.
The first author wishes to thank the Kuopio University Hospital for the EVO research grant as well as the Finnish Cultural Foundation. The 9th author wishes to thank the Kuopio University Hospital for EVO research grant, Emil Aaltonen Foundation and the Finnish Medical Foundation. The study design was reviewed and approved by the Ethics Committee of University of Eastern Finland, Kuopio, Finland and Kuopio University Hospital, Finland, and experiments were in compliance with Finnish law.
BMC Musculoskelet Disord. 2014;15(348) © 2014 BioMed Central, Ltd.
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