Ultrastructural Characterization of Primary Cilia in Pathologically Characterized Human Glioblastoma Multiforme (GBM) Tumors

Joanna J Moser; Marvin J Fritzler; Jerome B Rattner


BMC Clin Pathol. 2014;14(40) 

In This Article


The major finding of this report is that primary ciliogenesis is disrupted at an early stage in the majority of human GBM tumors. This finding is important for several reasons. First, these results confirm astrocytoma/glioblastoma cell culture data. Second, it indicates that defects in ciliogenesis are a hallmark of GBM tumor pathology and provides impetus for further study of the relationship between primary cilium defects and other brain tumors such as astrocytoma, oligodendroglioma and medulloblastoma. Third, it provides further evidence that the early stages of ciliogenesis are a critical time in the process of ciliogenesis, thus narrowing the number of target proteins that may underlie these defects. Fourth, it catalogues and describes the key basal body/cilium-related ultrastructural abnormalities that are common between GBM tumors. The ultrastructural description of this study informs which proteins are involved in early ciliogenesis defects and identifies candidates that are currently in the literature. In future, it will be important to elucidate which specific proteins are involved in this critical time period and whether alterations in their expression can restore ciliogenesis and thus restore cell cycle control.