100 Most Prescribed, Best-Selling Branded Drugs Through September

Troy Brown, RN

November 03, 2014

The cholesterol-lowering drug rosuvastatin (Crestor, AstraZeneca) edged out the hypothyroid drug levothyroxine (Synthroid, AbbVie) as the most prescribed drug in the United States, and the antipsychotic medication aripiprazole (Abilify, Otsuka Pharmaceutical) remains the best-selling drug, according to recent data.

Research firm IMS compiled a rolling 12-month history (October 2013 to September 2014) of the top 100 drugs by total prescriptions and total sales in the United States.

Rosuvastatin had about 22.3 million prescriptions, followed by levothyroxine, at about 22.3 million prescriptions; proton pump inhibitor esomeprazole (Nexium, AstraZeneca), at about 17.8 million prescriptions; and the asthma medications albuterol (Ventolin HFA, GlaxoSmithKline), at about 17.8 million prescriptions, and fluticasone propionate/salmeterol (Advair Diskus, GlaxoSmithKline), at about 14.5 million prescriptions.

The remaining top 10 most prescribed drugs for the period (in order) were the insulin glargine injection (Lantus Solostar, sanofi-aventis), the attention-deficit drug lisdexamfetamine dimesylate (Vyvanse, Shire), the antiepileptic drug pregabalin (Lyrica, Pfizer), the chronic obstructive pulmonary disease medication tiotropium bromide (Spiriva Handihaler, Boehringer Ingelheim Pharmaceuticals), and the antihypertensive drug valsartan (Diovan, Novartis).

Top-Selling

Aripiprazole had sales of $7.5 billion, followed by the arthritis drug adalimumab (Humira, Abbott Laboratories, $6.7 billion), hepatitis C drug sofosbuvir (Sovaldi, Gilead Sciences, $6.7 billion), esomeprazole (Nexium, AstraZeneca, $6.1 billion), and rosuvastatin (Crestor, AstraZeneca, $5.8 billion).

Rounding out the top 10 in sales were the arthritis drug etanercept (Enbrel, Amgen, $5.3 billion), fluticasone propionate/salmeterol (Advair Diskus, GlaxoSmithKline, almost $5 billion), the arthritis drug infliximab (Remicade, Centocor, $4.5 billion), the insulin glargine injection (Lantus Solostar, sanofi-aventis, $4.1 billion), and the neutropenia drug pegfilgrastim (Neulasta, Amgen, $3.8 billion).

Table 1. Top 100 Prescriptions, Sales
Product Prescriptions, n
Crestor 22,279,247
Synthroid 22,258,461
Nexium 17,763,935
Ventolin HFA 17,745,136
Advair Diskus 14,495,507
Lantus Solostar 10,450,322
Vyvanse 10,147,910
Lyrica 9,798,532
Spiriva Handihaler 9,555,794
Diovan 9,470,735
Lantus 9,283,819
Januvia 8,840,911
Abilify 8,825,094
Celebrex 8,722,291
Cialis 7,542,063
Viagra 7,431,369
Symbicort 7,416,869
Zetia 7,243,535
Nasonex 7,099,068
Suboxone 6,997,562
Namenda 6,908,201
Bystolic 6,665,853
Levemir 5,872,711
Xarelto 5,723,115
Flovent HFA 5,637,690
Oxycontin 5,505,961
Cymbalta 5,491,281
Nuvaring 4,986,756
Thyroid 4,970,116
Voltaren Gel 4,890,248
Dexilant 4,772,598
Benicar 4,640,020
Proventil HFA 4,532,962
Tamiflu 4,170,629
Novolog Flexpen 4,056,670
Humalog 4,009,248
Novolog 3,988,984
Premarin 3,795,768
Vesicare 3,790,832
Benicar HCT 3,539,522
Afluria 3,388,174
Lumigan 3,315,225
Lo Loestrin Fe 3,227,089
Janumet 3,064,731
Ortho-Tri-Cy Lo 28 2,995,623
Combivent Respimat 2,965,358
Toprol-XL 2,944,217
Pristiq 2,935,525
Travatan Z 2,890,189
Pataday 2,813,903
Humalog Kwikpen 2,799,179
Vytorin 2,772,857
Minastrin 24 Fe 2,711,030
Focalin XR 2,689,816
Avodart 2,460,223
Seroquel XR 2,403,366
Strattera 2,387,721
Pradaxa 2,382,389
Chantix 2,165,904
Zostavax 2,104,519
Namenda XR 2,023,583
Humira 1,989,802
Dulera 1,981,166
Victoza 3-Pak 1,960,970
Lunesta 1,868,471
Exelon 1,863,529
Combigan 1,857,527
Onglyza 1,768,340
Exforge 1,762,355
Welchol 1,743,549
Premarin Vaginal 1,738,140
Enbrel 1,651,478
Ranexa 1,605,867
Invokana 1,586,550
Evista 1,573,950
Truvada 1,568,162
Tradjenta 1,528,164
Alphagan P 1,499,787
Viibryd 1,451,898
Effient 1,432,066
Xopenex HFA 1,430,199
Azor 1,409,658
Norvir 1,388,745
Amitiza 1,323,651
Latuda 1,312,129
Lotemax 1,278,211
Advair HFA 1,277,054
Uloric 1,260,622
Patanol 1,240,388
Asmanex Twisthaler 1,228,416
Aggrenox 1,226,201
Eliquis 1,219,016
Linzess 1,181,435
Atripla 1,175,163
Levitra 1,161,618
Epiduo 1,155,645
Actonel 1,124,413
Prempro Low Dose 1,119,107
Novolog Flxpen Mix 70/30 1,104,925
Lipitor 1,085,544
Grand total 435,891,857
Table 2. Top 100 Prescriptions, Dollars
Product Sales
Abilify $7,545,171,814
Humira $6,732,549,721
Sovaldi $6,707,188,529
Nexium $6,140,633,073
Crestor $5,771,965,582
Enbrel $5,294,762,089
Advair Diskus $4,951,078,263
Remicade $4,462,708,246
Lantus Solostar $4,141,633,161
Neulasta $3,773,342,168
Copaxone $3,767,984,707
Rituxan $3,424,156,083
Januvia $3,293,105,892
Spiriva Handihaler $3,287,988,871
Lantus $3,210,967,627
Lyrica $2,940,486,769
Atripla $2,936,051,617
Avastin $2,839,069,590
Celebrex $2,540,107,019
Oxycontin $2,512,575,981
Truvada $2,415,534,718
Epogen $2,404,513,411
Levemir $2,379,861,112
Tecfidera $2,272,366,315
Gleevec $2,200,372,454
Herceptin $2,114,710,693
Symbicort $2,065,868,335
Vyvanse $2,017,878,965
Zetia $1,989,871,625
Lucentis $1,935,918,100
Diovan $1,822,322,799
Xarelto $1,820,855,491
Novolog Flexpen $1,817,768,346
Namenda $1,663,323,838
Olysio $1,613,380,132
Humalog $1,543,386,296
Novolog $1,521,160,839
Cymbalta $1,435,717,923
Suboxone $1,400,974,587
Tysabri $1,369,210,575
Stelara $1,354,608,832
Victoza 3-Pak $1,354,357,966
Cialis $1,309,376,569
Seroquel XR $1,297,174,809
Viagra $1,292,109,794
Humalog Kwikpen $1,272,391,115
Alimta $1,228,096,169
Gilenya $1,209,963,678
Nasonex $1,188,081,443
Stribild $1,149,073,889
Flovent HFA $1,122,295,786
Prezista $1,121,162,004
Janumet $1,116,205,392
Avonex $1,110,939,062
Renvela $1,081,550,789
Dexilant $1,049,502,432
Orencia $1,045,004,551
Isentress $1,044,905,638
Vesicare $1,024,006,819
Procrit $994,494,946
Avonex Pen $986,796,226
Zytiga $980,859,486
Latuda $972,259,015
Xolair $969,656,691
Synthroid $969,060,446
Invega Sustenna $943,606,764
Benicar $921,872,275
Reyataz $909,285,338
Sensipar $896,544,366
Combivent Respimat $894,452,705
Pradaxa $885,423,590
Neupogen $883,026,687
Xgeva $881,985,375
Afinitor $835,049,543
Prevnar 13 $834,053,949
Complera $821,426,403
Aranesp $820,202,858
Vytorin $800,719,271
Ventolin HFA $793,242,314
Betaseron $779,842,084
Bystolic $765,343,634
Synagis $753,273,011
Zyvox $739,246,263
Cimzia $736,446,313
Gardasil $728,326,881
Benicar HCT $721,782,298
Sandostatin LAR $720,355,549
Pristiq $703,798,575
Treanda $686,115,677
Strattera $684,242,163
Sprycel $677,924,580
Erbitux $672,602,355
Cubicin $656,709,379
Zostavax $655,785,081
Velcade $648,461,251
Abraxane $647,920,779
Tarceva $646,356,078
Lunesta $575,643,680
Xeloda $502,312,799
Evista $440,121,056
Grand total $178,585,957,827

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