Management of Acute Diabetic Foot Disease

Oluwaranti Akiyode, PharmD, BCPS, CDE; Bryan Sackey, PharmD Candidate 2015, BS


US Pharmacist 

In This Article

Abstract and Introduction


Diabetic foot disease is a broad spectrum of foot disorders involving the cutaneous, soft-tissue, and osseous structures. Acute conditions may manifest as deeply infected wounds with extensive structural damage necessitating immediate medical attention to avoid amputation. Peripheral neuropathy, tissue ischemia, and foot biomechanics play a role in the development of acute ulcerative conditions. Some common offending agents in acute infections include gram-positive cocci and gram-negative bacilli. Early recognition and treatment by a multidisciplinary healthcare team are necessary for complete therapeutic resolution in patients who present with acute conditions. Pharmacists play an integral role in assessing the appropriateness of therapeutic regimens, as well as in educating patients upon discharge in order to prevent exacerbation of the condition.


Diabetic foot disease (DFD) is a spectrum of disorders involving the cutaneous, soft-tissue, and osseous structures of the foot. This includes the development of foot ulcers and infections that may develop into limb-threatening conditions. Early recognition and management of acute DFD are critical for the prevention of disease progression and amputation. This review is intended to educate pharmacists regarding the proper management of acute DFDs according to current guidelines.