A Clinical Update

Nonceliac Gluten Sensitivity—Is it Really the Gluten?

Bernadette Capili, PhD, NP-C; Michelle Chang, MS; Joyce K. Anastasi, PhD, DrNP


Journal for Nurse Practitioners. 2014;10(9):666-673. 

In This Article

What is NCGS?

NCGS is an entity distinct from CD and is currently defined as a nonallergic and non-autoimmune condition in which the consumption of gluten can lead to symptoms similar to those seen in CD.[8] Although it can occur at any age, gluten sensitivity seems to be more frequent in adults than in children and more prevalent in females than in males.[13] The pathogenesis of this condition remains unclear, but possible roles of the innate immune system and intestinal permeability are indicated.[8,14] The symptoms of bloating, abdominal pain, diarrhea, and constipation may also seem similar to irritable bowel syndrome, but more often with non-GI symptoms (headache, "brain fog," fatigue, skin disorders such as eczema or rash, and joint pain) (Table 1). More severe neurologic and psychiatric conditions have also been reported to be associated with gluten sensitivity, but data are insufficient and the topic remains controversial.[15]