Statins: The Good, the Bad, and the Unknown

Clinicians Are Talking About Statins

Gordon H. Sun, MD, MS

October 10, 2014

Conclusions

In summary, several important issues were broached in comments by Medscape readers, reflecting the notable controversy generated by the latest ACC/AHA guidelines, nearly a year after publication:

• Up-to-date meta-analyses of statin use as primary prevention in women and the elderly have provided further evidence of their usefulness in these populations, although some of the literature was inconclusive and many Medscape readers remain skeptical.

• Myopathy potentially related to statin use was the most commonly reported adverse event by Medscape readers.

• Medscape readers were concerned that the guidelines did not sufficiently emphasize the benefits of positive lifestyle habits on prevention of CVD. A randomized trial comparing statins with beneficial lifestyle changes and examining clinical outcomes has yet to be conducted.

• Studies contrasting statin use and healthy lifestyle adherence—the "statin-lifestyle interaction"—demonstrate conflicting results. Recent research hypothesized that statin-related myopathy might actually compromise the ability to exercise, thus complicating patients' ability to adhere to good lifestyle habits.

It would be fair to say that this debate is far from settled.

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Cite this: Gordon H. Sun. Statins: The Good, the Bad, and the Unknown - Medscape - Oct 10, 2014.

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