Community-Associated Methicillin-Resistant Staphylococcus Aureus and HIV

Yoona Rhee; Kyle J Popovich


Future Virology. 2014;9(6):531-535. 

In This Article

Abstract and Introduction


Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as an important pathogen in the community within the last 10–15 years – so-called community-associated MRSA (CA-MRSA).[1,2] Outbreaks have been described among children in daycares,[1] amateur and professional athletes,[3,4] military personnel,[5] inmates in correctional facilities,[6] and men who have sex with men (MSM).[7] Most CA-MRSA strains lead to minor skin and soft tissue infections (SSTI),[1,8] but invasive diseases such as necrotizing fasciitis,[9] necrotizing pneumonia[10,11] and bacteremia[12] can occur.

Patients with HIV have been significantly impacted by the CA-MRSA epidemic, with high levels of CA-MRSA colonization[13–15] and infection[16,17] reported. As increased risk for CA-MRSA has been observed even among HIV-infected patients with well-controlled disease,[15] ref- it has been speculated that factors beyond immune suppression play a role in CA-MRSA risk. Studies have suggested that location and type of residence,[17,18] incarceration exposure,[19] illicit drug use[13,20] and high-risk social networks[7] may be associated with risk for CA-MRSA.