The Child With Difficult to Control Congenital Adrenal Hyperplasia

Is There a Place for Continuous Subcutaneous Hydrocortisone Therapy

Peter C. Hindmarsh

Disclosures

Clin Endocrinol. 2014;81(1):15-18. 

In This Article

Abstract and Introduction

Abstract

The treatment of congenital adrenal hyperplasia requires administration of glucocorticoid and mineralocorticoid to replace the deficit resulting from the enzymatic block. During puberty, cortisol metabolism changes with an increase in clearance, which may lead to unstable control. This may require an increase in dosing frequency, and if this proves problematic, continuous subcutaneous hydrocortisone delivery using insulin pump technology can be valuable. The potential indications for such therapy along with some practical considerations are detailed in this Clinical Question report.

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