Microbiome and Probiotics: Link to Arthritis

Mohamed K. Bedaiwi; Robert D. Inman


Curr Opin Rheumatol. 2014;26(4):410-415. 

In This Article


Microbiota have a substantive impact on the immune system development and it remains an attractive, but unproven, theory that predisposing genetic factors may interact with microbiota to trigger peripheral or axial arthritis. Table 1 presents a list of pathogens that have been linked to arthritis.

Our review summarizes the recent evidence of oral and lung organisms in relation to RA. Regarding SpA, the recent finding of a correlation of axial inflammation, as detected by MRI, with subclinical gut inflammation may support the previous finding of gut–joint interactions in HLA-B27 transgenic rats. More evidence is needed to confirm the impact of the role of microbiota in arthritis, and further studies are needed to evaluate the role of probiotics as a novel therapeutic modality for arthritis.