Polysubstance Use: Diagnostic Challenges, Patterns of Use and Health

Jason P. Connor; Matthew J. Gullo; Angela White; Adrian B. Kelly


Curr Opin Psychiatry. 2014;27(4):269-275. 

In This Article


It is clear that individuals who use multiple substances are at elevated risk of developing comorbid psychiatric and other health conditions. They also have more pervasive deficits in cognitive functioning that place them at elevated risk of poorer treatment outcomes. Prevention and treatment approaches for polysubstance use are underdeveloped by comparison with treatments for abuse of single substances. Future research will tell what effects removing polysubstance dependence from DSM-5 will have on the identification and treatment of this group of substance users.