Primary Spine Tumors: Diagnosis and Treatment

Michelle J. Clarke, MD; Ehud Mendel, MD; Frank D. Vrionis, MD, PhD


Cancer Control. 2014;21(2):114-123. 

In This Article


Once the diagnosis and the metastatic disease burden are established, attention should be turned to treatment. Patients with primary tumors require a multidisciplinary approach involving medical oncology, radiation oncology, and spine surgery specialties. Coordination of care is paramount to optimize the response for each treatment modality.

Chemotherapy/Radiation Responsivity

Primary tumors fall into 2 basic categories, ie, those responsive to radiation and chemotherapeutic agents and those unresponsive to such treatment modalities. Primary tumors of the spine that respond well to adjuvant therapies include hematopoietic lesions and certain sarcomas.