In conclusion, in patients with type 2 diabetes, all studied doses of SGLT2 inhibitors either as monotherapy or in combination with other antidiabetic agents improved glycemic control consistently. Furthermore SGLT2 inhibitors were associated with a significant reduction in body weight and blood pressure. However, a small percentage of patients suffer from genital and urinary tract infections. Yet, SGLT2 inhibitors appear to be safe as the number of hypoglycemic events and the number of patients who discontinued therapy were similar between SGLT2 inhibitor treated groups from placebo treated patients. Finally, further investigations with long term duration of therapy are needed to establish the safety and efficacy of SGLT2 inhibitors.
The authors declare that they have no competing interests.
ABe: conceived and designed the study, conducted the analysis, wrote the manuscript and participated in the literature search, study selection and data abstraction. ABa: reviewed and edited the manuscript and participated in the literature search, study selection and data abstraction. Both authors read and approved the final manuscript.
The authors would like to acknowledge WHO and major publishers for setting up HINARI (Health InterNetwork Access to Research Initiative). To conduct this meta- analysis the authors have not got any financial or technical support.
BMC Endocr Disord. 2013;13(58) © 2013 BioMed Central, Ltd.