Sodium Glucose Co-transport 2 Inhibitors in the Treatment of Type 2 Diabetes Mellitus

A Meta-analysis of Randomized Double-Blind Controlled Trials

Asres Berhan; Alex Barker


BMC Endocr Disord. 2013;13(58) 

In This Article


In conclusion, in patients with type 2 diabetes, all studied doses of SGLT2 inhibitors either as monotherapy or in combination with other antidiabetic agents improved glycemic control consistently. Furthermore SGLT2 inhibitors were associated with a significant reduction in body weight and blood pressure. However, a small percentage of patients suffer from genital and urinary tract infections. Yet, SGLT2 inhibitors appear to be safe as the number of hypoglycemic events and the number of patients who discontinued therapy were similar between SGLT2 inhibitor treated groups from placebo treated patients. Finally, further investigations with long term duration of therapy are needed to establish the safety and efficacy of SGLT2 inhibitors.