Characteristics and Factors Associated With the Clinical Forms of Lipoatrophy During Highly Active Antiretroviral Therapy in Ouagadougou, Burkina Faso

Oumar Guira, MD; Hervé Tiéno, MD; Bertille Yaméogo, MD; Arnaud Eric Diendéré, MD; Nina Korsaga, MD; Yempabou Sagna, MD; Lassané Zoungrana, MD; Ismael Diallo, MD; René Traoré, MD; Joseph Youssouf Drabo, MD

Disclosures

J Int Assoc Provid AIDS Care. 2014;13(2):184-187. 

In This Article

Results

Epidemiological and Clinical Features of Lipoatrophy

Three hundred patients were studied; the sex ratio was 0.4 and mean age was 42.1 ± 8.5 years. The mean duration of HAART was 73.2 ± 30.9 months. The main HAART regimens noted were zidovudine (ZDV)/lamivudine (3TC)/nevirapine (NVP) (32.3%); stavudine (d4T)/3TC/NVP (26.3%), and ZDV/3TC/efavirenz (EFV; 14.3%). Of these patients, 97 (32.3%) had lipoatrophy, including 75 (25%) isolated lipoatrophy and 22 (7.3%) mixed syndrome. Thirty-one (10.3%) patients had isolated lipohypertrophy. Table 1 shows the demographic and anthropometric features in different groups of patients.

Lipoatrophy affected the face, lower limbs, buttocks, and upper limbs, respectively, in 60 (61.8%), 22 (22.7%), 21 (21.6%), and 10 (10.3%) patients. Forty-five (46.4%) patients had lipoatrophy with multiple localizations.

Factors Associated With Different Forms of Lipoatrophy

As factors related to lifestyle, smoking was reported by 5 (6.7%) patients who presented with lipoatrophy, 4 (18.2%) with mixed syndrome, and 4 (2%) without lipoatrophy (P = .001). The practice of physical activity was reported by 7 (9.3%) patients with isolated lipoatrophy, 3 (13.6%) with mixed syndrome, and 5 (2.5%) without lipoatrophy (P = .003).

The baseline CD4 count was lower than 200 cells/mm3 in 36 (48%) patients with isolated lipoatrophy, 7 (31.8%) with mixed syndrome, and 105 (51.7%) without lipoatrophy; P = .20. Table 2 and Table 3, respectively, show the demographic and anthropometric and the therapeutic factors associated with different phenotypes of lipoatrophy.

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