Serum-specific IgE and Allergen Immunotherapy in Allergic Children

Mariangela Tosca; Michela Sivestri; Andrea Accogli; Giovanni Arturo Rossi; Giorgio Ciprandi


Immunotherapy. 2014;6(1):29-33. 

In This Article


The availability of a biomarker that predicts the AIT outcome would be extremely useful in clinical practice, but it should be reliable and easily achievable. Serum-sIgE assay is a popular test, commonly used by the allergist. Moreover, positive IgE is a typical marker for the allergic phenotype and high serum-sIgE levels may be associated with symptom severity.[14]

The present study also confirms that the sIgE levels in allergic children may be associated with AIT response. In other words, a sIgE level >10 kU/l before AIT prescription could advise the allergist that AIT might have a good chance of efficacy.

In conclusion, allergen-sIgE assessment before AIT prescription might represent a useful tool to individuate potential responders.