Predictors of Chronic Obstructive Pulmonary Disease Exacerbations

Takeo Ishii; Kozui Kida


Curr Opin Pulm Med. 2014;20(2):138-145. 

In This Article

The State of Current Research on Exacerbations: Genetic Factors Decreasing Immunity

The frequent-exacerbation phenotype is relatively stable,[7] which suggests the presence of contributing genetic factor(s). Several reports exist regarding the association between exacerbation susceptibility and some gene variations, including surfactant protein B,[24] mannose-binding lectin,[25] and chemokine ligand 1;[26] the proteins coded by these genes are a surfactant protein, a lectin that acts as a pattern-recognition receptor in serum, and a chemokine, respectively, and they mainly have the capacity to protect against bacteria or viruses. The genetic variations that increase this capacity are thought to reduce susceptibility to infection, and thus COPD exacerbations.

It was also reported that an immunoglobulin G titer for a periodontitis-related antibody was related to exacerbation frequency.[27] Further investigation is needed regarding the role of acquired immunity and aspiration pneumonia in COPD exacerbations, as well as the role of vaccinations.