Top 100 Selling Drugs of 2013

Megan Brooks

January 30, 2014

Hypothyroid medication levothyroxine (Synthroid, AbbVie) was the nation's most prescribed drug in 2013, whereas the antipsychotic aripiprazole (Abilify, Otsuka Pharmaceutical) had the highest sales, at nearly $6.5 billion, according to a new report from research firm IMS Health on the top 100 selling drugs in the United States.

Following levothyroxine as most prescribed were the cholesterol-lowering drug rosuvastatin (Crestor, AstraZeneca), the proton-pump inhibitor esomeprazole (Nexium, AstraZeneca), and the antidepressant duloxetine (Cymbalta, Eli Lilly).

Rounding out the top 10 most prescribed drugs in 2013 (in order) were the asthma drugs albuterol (Ventolin, HFA) and fluticasone propionate/salmeterol (Advair Diskus, GlaxoSmithKline), the antihypertensive valsartan (Diovan, Novartis), the attention deficit drug lisdexamfetamine dimesylate (Vyvanse, Shire), the antiepileptic pregabalin (Lyrica, Pfizer), and the chronic obstructive pulmonary disease drug tiotropium bromide (Spiriva, Boehringer Ingelheim).

After aripiprazole, the next best selling drugs in 2013 were Nexium, at $6.1 billion, and the arthritis drug adalimumab (Humira, AbbVie), at $5.5 billion.

Rounding out the top 10 in sales were Crestor ($5.3 billion), Cymbalta ($5.2), Advair Diskus ($5.1 billion), the arthritis drugs etanercept (Enbrel, Amgen; $4.6 billion) and infliximab (Remicade, Centocor; $4.1 billion), the multiple sclerosis drug glatiramer acetate (Copaxone, Teva Pharm; $3.7 billion), and neutropenia drug pegfilgrastim (Neulasta, Amgen; $3.6 billion).

Table 1. Top 100 Drugs by Sales
Rank Drug (brand name) Sales, 2013
1 Abilify $6,460,215,394
2 Nexium $6,135,667,614
3 Humira $5,549,996,855
4 Crestor $5,310,818,889
5 Cymbalta $5,219,860,418
6 Advair Diskus $5,121,312,668
7 Enbrel $4,681,201,645
8 Remicade $4,098,233,242
9 Copaxone $3,697,182,238
10 Neulasta $3,580,364,758
11 Rituxan $3,288,614,045
12 Lantus Solostar $3,005,681,663
13 Spiriva Handihaler $2,998,207,542
14 Atripla $2,856,818,557
15 Januvia $2,843,496,907
16 Avastin $2,688,414,938
17 Lantus $2,556,825,619
18 Oxycontin $2,534,909,675
19 Lyrica $2,415,254,835
20 Epogen $2,280,696,834
21 Celebrex $2,237,658,764
22 Truvada $2,235,712,145
23 Diovan $2,169,819,482
24 Herceptin $1,938,804,857
25 Gleevec $1,896,982,614
26 Lucentis $1,859,463,484
27 Namenda $1,856,822,750
28 Vyvanse $1,743,115,521
29 Zetia $1,710,526,476
30 Symbicort $1,563,242,161
31 Levemir $1,547,629,745
32 Suboxone $1,450,554,130
33 Novolog Flexpen $1,377,221,614
34 Novolog $1,349,403,122
35 Avonex $1,240,754,136
36 Seroquel Xr $1,226,532,019
37 Viagra $1,196,812,385
38 Alimta $1,192,134,813
39 Humalog $1,184,189,487
40 Nasonex $1,137,402,455
41 Victoza 3-Pak $1,104,811,637
42 Cialis $1,086,355,583
43 Gilenya $1,059,346,323
44 Flovent Hfa $1,050,009,900
45 Procrit $1,030,419,958
46 Isentress $1,014,678,055
47 Xarelto $996,441,091
48 Prezista $992,087,940
49 Janumet $987,663,598
50 Stelara $965,072,892
51 Neupogen $958,807,372
52 Orencia $957,680,500
53 Renvela $955,330,199
54 Reyataz $934,879,388
55 Vesicare $933,311,254
56 Dexilant $916,401,204
57 Tecfidera $879,673,483
58 Humalog Kwikpen $879,632,962
59 Synthroid $858,725,708
60 Vytorin $858,576,112
61 Lunesta $851,791,226
62 Pradaxa $836,573,805
63 Benicar $832,276,970
64 Evista $823,647,433
65 Xolair $821,783,471
66 Aranesp $809,245,700
67 Prevnar 13 $806,129,346
68 Sensipar $786,320,942
69 Xgeva $785,725,436
70 Invega Sustenna $779,834,172
71 Zytiga $775,269,249
72 Avonex Pen $768,655,140
73 Synagis $767,786,422
74 Betaseron $767,648,290
75 Xeloda $754,133,787
76 Ventolin Hfa $745,629,470
77 Zyvox $726,184,205
78 Afinitor $721,629,719
79 Gardasil $710,208,856
80 Zostavax $705,140,729
81 Incivek $701,317,408
82 Sandostatin Lar $697,961,265
83 Aciphex $683,359,951
84 Benicar Hct $681,353,719
85 Bystolic $681,318,227
86 Treanda $679,052,250
87 Focalin Xr $660,161,202
88 Erbitux $648,984,405
89 Tamiflu $641,134,799
90 Tarceva $640,597,157
91 Pristiq $632,619,542
92 Complera $630,039,312
93 Cubicin $628,034,439
94 Velcade $621,800,823
95 Strattera $616,604,042
96 Viread $599,074,197
97 Stribild $598,844,153
98 Welchol $573,939,710
99 Combivent Respimat $573,179,772
100 Xifaxan $569,762,570
Source: IMS National Prescription Audit, IMS Health
Table 2. Top 100 Drugs by Monthly Prescriptions
Rank Drug (brand name) Total prescriptions, 2013*
1 Synthroid 23,452,848
2 Crestor 23,292,568
3 Nexium 20,156,519
4 Cymbalta 18,864,818
5 Ventolin Hfa 17,371,422
6 Advair Diskus 16,290,417
7 Diovan 12,656,244
8 Vyvanse 10,525,976
9 Lyrica 9,560,440
10 Spiriva Handihaler 9,516,246
11 Lantus Solostar 9,365,899
12 Lantus 9,276,262
13 Celebrex 9,205,630
14 Abilify 8,964,479
15 Januvia 8,685,759
16 Namenda 8,545,395
17 Nasonex 8,144,373
18 Viagra 7,671,000
19 Zetia 7,654,329
20 Cialis 7,523,724
21 Suboxone 7,494,065
22 Bystolic 6,823,634
23 Symbicort 6,155,515
24 Flovent Hfa 6,034,261
25 Oxycontin 5,926,600
26 Tamiflu 5,573,597
27 Nuvaring 5,251,818
28 Dexilant 5,151,097
29 Afluria 5,088,178
30 Levemir 4,946,820
31 Benicar 4,941,124
32 Proventil Hfa 4,487,576
33 Premarin 4,423,103
34 Thyroid 4,417,055
35 Voltaren Gel 4,361,311
36 Novolog 4,160,063
37 Vesicare 4,038,929
38 Novolog Flexpen 3,904,106
39 Benicar Hct 3,864,614
40 Humalog 3,588,291
41 Xarelto 3,584,743
42 Vytorin 3,483,951
43 Lunesta 3,443,227
44 Focalin Xr 3,437,424
45 Toprol-Xl 3,363,632
46 Ortho-Tri-Cy Lo 28 3,336,409
47 Pristiq 3,322,816
48 Lumigan 3,255,306
49 Loestrin 24 Fe 3,224,378
50 Janumet 3,171,889
51 Lo Loestrin Fe 3,092,756
52 Travatan Z 3,026,842
53 Evista 2,947,634
54 Pataday 2,780,125
55 Avodart 2,689,644
56 Pradaxa 2,580,518
57 Zostavax 2,521,291
58 Seroquel Xr 2,515,894
59 Strattera 2,509,390
60 Humalog Kwikpen 2,317,553
61 Detrol La 2,203,287
62 Chantix 2,186,881
63 Xopenex Hfa 2,066,174
64 Exforge 1,952,589
65 Combivent Respimat 1,941,907
66 Exelon 1,896,536
67 Humira 1,869,383
68 Welchol 1,834,562
69 Combigan 1,790,758
70 Victoza 3-Pak 1,770,921
71 Onglyza 1,726,906
72 Premarin Vaginal 1,719,938
73 Lipitor 1,706,228
74 Trilipix 1,668,031
75 Actonel 1,656,159
76 Enbrel 1,647,506
77 Truvada 1,598,212
78 Combivent 1,568,466
79 Aciphex 1,563,732
80 Alphagan P 1,524,870
81 Azor 1,516,004
82 Dulera 1,494,050
83 Micardis 1,481,385
84 Ranexa 1,462,285
85 Viibryd 1,459,314
86 Norvir 1,452,569
87 Patanol 1,417,850
88 Effient 1,415,883
89 Aggrenox 1,389,839
90 Advair Hfa 1,328,487
91 Amitiza 1,305,080
92 Prempro Low Dose 1,274,042
93 Atripla 1,269,883
94 Lotemax 1,265,850
95 Asmanex Twisthaler 1,249,428
96 Tradjenta 1,238,074
97 Ortho Evra 3 1,233,388
98 Uloric 1,219,323
99 Diovan Hct 1,217,689
100 Levitra 1,207,939
*New prescriptions and refills
Source: IMS National Prescription Audit, IMS Health

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