Searching for Mammary Analog Secretory Carcinoma of Salivary Gland Among Its Mimics

Andre Pinto; Vania Nosé; Claudia Rojas; Yao-Shan Fan; Carmen Gomez-Fernandez


Mod Pathol. 2014;27(1):30-37. 

In This Article


Mammary analog secretory carcinoma is a new diagnostic entity that should be in the differential diagnosis of salivary gland tumors that predominantly mimic acinic cell carcinoma. Although morphologically similar, they differ from conventional acinic cell carcinoma immunohistochemically and molecularly. They predominantly affect male patients. Positivity for mammaglobin and S-100 and negativity for ANO1 are useful screening tools before further confirmatory cytogentic studies demonstrating the ETV6-NTRK3 fusion product.