Staphylococci: Colonizers and Pathogens of Human Skin

Rosanna Coates; Josephine Moran; Malcolm J Horsburgh


Future Microbiol. 2014;9(1):75-91. 

In This Article

RNase 5

RNase 5 has a well-described role in angiogenesis; however, Hooper et al. attributed its primary role as being antimicrobial defense of the epidermis since its gene expression does not correlate temporally with angiogenesis.[52] High mutation rates of RNase 5 are consistent with those of other antimicrobial factors under selective pressure.[53] Hooper et al. observed that RNase 5 significantly reduced viability of Candida albicans and Streptococcus pneumoniae.[52] Although this potency was not easily reproduced by others,[54] narrow spectrum bactericidal activity was confirmed,[55] as was the capacity of the human epidermis to produce RNase 5.[56] RNase 5 functions under similar physiological conditions, such as pH and salt concentration, as other AMPs.[52] Overall, the extent to which RNase 5 contributes to the epidermal barrier remains unclear.