Clinical Differentiation of Bipolar II Disorder From Borderline Personality Disorder

Adam Bayes; Gordon Parker; Kathryn Fletcher


Curr Opin Psychiatry. 2014;27(1):14-20. 

In This Article


Both conditions are associated with an increased risk of anxiety and substance abuse disorders in particular,[2,44,81] although varying study methodologies make comparative analyses difficult to interpret. In a sample of those with BP II, the lifetime over-representation of anxiety disorders was quantified,[82] with an odds ratio of 9.1 for any anxiety disorder. Comorbid attention deficit hyperactivity disorder (ADHD) appears to also be an over-represented feature of bipolar,[23] with an OR of 9.2 quantified in those with BP II,[82] but without a comorbidity rate formally quantified for BPD. It is unclear whether comorbidity is greater between bipolar and BPD relative to other personality disorders, with mixed results reported.[37,41,83–85] The majority of people diagnosed with one disorder (i.e. bipolar or BPD) do not have the other,[11] supporting differentiation of the two conditions.