Clinical Differentiation of Bipolar II Disorder From Borderline Personality Disorder

Adam Bayes; Gordon Parker; Kathryn Fletcher


Curr Opin Psychiatry. 2014;27(1):14-20. 

In This Article

Neuroimaging Findings

Structural and functional neuroimaging studies investigating bipolar and BPD have been reviewed by Coulston et al.[4] and Mauchnik and Schmahl[62]; however, none analyzed sufficient numbers of BP II patients. Frontolimbic network dysfunction is apparent in both BPD and bipolar disorder (as reviewed in).[4] However, Malhi et al.[63] reported differential engagement of frontolimbic emotion processing distinguishing bipolar from BPD, with increased dorsomedial prefrontal cortex activity in bipolar patients and diminished amygdala activity in BPD. Such differing neural processing may underpin the emotional dysregulation observed in the two diagnostic conditions.