Treatment of Ulcerative Colitis

Wojciech Blonski; Anna M. Buchner; Gary R. Lichtenstein


Curr Opin Gastroenterol. 2014;30(1):84-96. 

In This Article


Treatment of ulcerative colitis is sequential and tailored to the individual patient without the presence of a single universally effective medication (Figs. 1 and 2).[68] In mild-to-moderate active extensive ulcerative colitis, therapy with oral 5-ASA medication is recommended and if there is no response, a course of corticosteroids might be required. Patients who respond to corticosteroids should be switched to AZA/6-mercaptopurine with subsequent gradual tapering of corticosteroids. Infliximab, ADA or golimumab might be introduced in patients who do not respond to conventional treatment with corticosteroids and AZA/6-mercaptopurine. Success of therapy of ulcerative colitis depends on optimization of each step of management and considerable clinical judgment about each outcome.

Figure 1.

Treatment algorithm of mild-to-moderate ulcerative colitis. Reproduced from [68].

Figure 2.

Treatment algorithm of moderate-to-severe ulcerative colitis. Authors' original figure. Modified from [68].