Introducing New Vaccines in Developing Countries

Sonali Kochhar; Barbara Rath; Lea D Seeber; Gabriella Rundblad; Ali Khamesipour; Mohammad Ali


Expert Rev Vaccines. 2013;12(12):1465-1478. 

In This Article

Expert Commentary

There is an urgent need for more global consensus and a tightly coordinated, comprehensive and compassionate approach to vaccine introduction. Vaccine-preventable diseases do not respect political borders!

The impact of World Wide Web and social media on vaccine acceptance cannot be overestimated. Intelligent tools for the monitoring of vaccine acceptance and vaccine safety will have a major impact. The Internet is a double-edged sword as it is used for spreading rumors but also as a tool to monitor and counteract rumors and fears.

Need for improved rapid diagnostics and effective real-time monitoring of VPD prior to vaccine introduction. The results of this research on the overall disease burden and costs to society as a whole, as well as the VPD risk to the individual, should be communicated to local health care workers as well as the general population prior to introduction of a new vaccine. A proactive rather than reactive approach should be pursued.

New vaccine designs and delivery systems need to be promoted. Preventing blood-borne infections are an important aspect of improving immunization safety. More vaccines of relevance to developing countries are under development. The specific demands of resource-poor settings should be considered at the design stage.

Last, but not the least, the question should be discussed openly how vaccine effectiveness will be defined in the context of low-resource settings. The strategy should move from 'number of lives saved at the end of the day' toward the 'prevention of suffering/disease burden'. New epidemiological models may be warranted to measure and adequately describe the real-world impact of vaccines.