Economic Implications of Potential Drug–Drug Interactions in Chronic Pain Patients

Robert Taylor Jr; Joseph V Pergolizzi Jr; R Amy Puenpatom; Kent H Summers


Expert Rev Pharmacoeconomics Outcomes Res. 2013;13(6):725-734. 

In This Article

Association Between DDEs & Health Service Use

The next question we asked was whether prevalence rates of these DDEs merit concern? In terms of health care services utilized, noncancer chronic pain patients who experienced a DDE utilized significantly more medical services. For example, DDE patients versus non-DDE patients experienced significantly more office visits (19.10 vs 18.29, p < 0.01), outpatient visits (6.71 vs 6.39, p < 0.01), emergency department visits (0.46 vs 0.43, p < 0.01), inpatient hospitalizations (0.13 vs 0.12, p < 0.01) and increased length of hospital stay (0.54 vs 0.47, p < 0.01).[31] Similar trends were seen for OA and cLBP patients. OA patients with DDEs had significantly more inpatient hospitalization than those without a DDE (p = 0.003 for younger [18–64 years old] and p = 0.025 for older patients [>65 years old]) while the cLBP group exposed to DDEs had statistically significantly more office visits for both younger (p = 0.045) and older (p = 0.002) groups.[29,30] These studies indicate that patients with chronic pain who experience a DDE may utilize more health care resources than those who do not experience a DDE.