Top 100 Selling Drugs Through September Reported

October 31, 2013

( Updated November 5, 2013 ) The cholesterol-lowering drug rosuvastatin (Crestor, AstraZeneca) was the nation's most prescribed drug over the course of last 12 months, through September, whereas the antipsychotic aripiprazole (Abilify, Otsuka Pharmaceutical) racked up the highest sales — almost $6.4 billion, according to a new report from research firm IMS Health on the top 100 selling drugs in the United States.

New prescriptions and refills of rosuvastatin totalled 23.7 million, edging out the hypothyroid medication levothyroxine (Synthroid, AbbVie) at 23.4 million scripts. Similar to several other drugs in the top 100 list for prescription volume, rosuvastatin also did well in sales, ranking fifth, with $5.3 billion in sales for the 12-month period. In contrast, levothyroxine ranked 60th in sales despite being heavily prescribed.

The 10 top-selling drugs reflect hardly any change since calendar year 2012, according to IMS Health.

Table 1. Top 100 Drugs by Total Sales

Rank Drug (brand name) Sales from October 1, 2012, through September 30, 2013
1 Abilify $6,391,050,009
2 Nexium $6,086,840,503
3 Cymbalta $5,432,152,672
4 Humira $5,352,226,238
5 Crestor $5,318,542,115
6 Advair Diskus $5,114,309,392
7 Enbrel $4,673,141,322
8 Remicade $4,058,128,532
9 Copaxone $3,788,545,102
10 Neulasta $3,537,574,204
11 Rituxan $3,298,174,917
12 Spiriva Handihaler $3,002,430,799
13 Atripla $2,912,549,658
14 Januvia $2,825,267,039
15 Lantus Solostar $2,778,551,072
16 Avastin $2,690,641,154
17 Oxycontin $2,637,737,756
18 Lantus $2,515,137,058
19 Lyrica $2,324,979,374
20 Truvada $2,278,264,056
21 Epogen $2,214,743,254
22 Celebrex $2,183,115,416
23 Diovan $2,137,198,878
24 Herceptin $1,933,127,070
25 Namenda $1,900,527,136
26 Gleevec $1,874,835,782
27 Lucentis $1,794,896,441
28 Vyvanse $1,709,395,031
29 Zetia $1,652,217,183
30 Suboxone $1,554,971,998
31 Symbicort $1,525,311,056
32 Levemir $1,447,476,053
33 Avonex $1,347,267,771
34 Novolog $1,330,347,675
35 Novolog Flexpen $1,317,460,587
36 Seroquel XR $1,219,959,533
37 Alimta $1,200,106,356
38 Viagra $1,197,351,402
39 Humalog $1,142,653,387
40 Nasonex $1,133,088,155
41 Flovent HFA $1,059,584,589
42 Cialis $1,049,194,980
43 Procrit $1,047,927,348
44 Victoza 3-Pak $1,041,143,228
45 Gilenya $1,025,284,670
46 Isentress $1,017,809,988
47 Neupogen $972,494,037
48 Reyataz $968,298,671
49 Janumet $967,434,639
50 Prezista $966,946,830
51 Orencia $935,878,810
52 Vesicare $911,521,673
53 Dexilant $894,524,903
54 Vytorin $891,763,516
55 Incivek $887,957,848
56 Renvela $881,552,606
57 Stelara $877,987,496
58 Pradaxa $858,826,893
59 Aranesp $845,994,421
60 Synthroid $843,417,754
61 Aciphex $830,120,367
62 Benicar $827,715,511
63 Humalog Kwikpen $827,032,048
64 Lunesta $822,435,175
65 Evista $822,388,181
66 Xolair $800,269,022
67 Betaseron $799,930,543
68 Prevnar 13 $798,920,861
69 Xarelto $778,365,806
70 Sensipar $763,591,668
71 Synagis $763,505,631
72 Xgeva $762,361,168
73 Ventolin HFA $750,667,410
74 Xeloda $747,260,480
75 Invega Sustenna $733,468,004
76 Zyvox $729,817,082
77 Zostavax $718,659,204
78 Zytiga $708,708,539
79 Gardasil $707,586,150
80 Sandostatin LAR $696,306,293
81 Combivent $693,216,113
82 Avonex Pen $691,914,191
83 Tamiflu $684,771,568
84 Benicar HCT $683,792,459
85 Treanda $681,499,807
86 Afinitor $680,545,083
87 Focalin XR $673,003,743
88 Bystolic $665,919,495
89 Erbitux $658,837,596
90 Tarceva $651,732,920
91 Cubicin $626,072,471
92 Pristiq $625,502,793
93 Velcade $622,009,646
94 Strattera $613,531,907
95 Revlimid $598,390,827
96 Viread $588,188,447
97 Detrol LA $571,448,481
98 Complera $570,267,495
99 Yervoy $569,112,697
100 Varivax $566,344,845

Source: IMS National Sales Perspectives, IMS Health

Table 2. Top 100 Drugs by Prescription Volume

Rank Drug (brand name) Total prescriptions* from October 1, 2012, through September 30, 2013
1 Crestor 23,736,568
2 Synthroid 23,407,581
3 Nexium 20,689,735
4 Cymbalta 19,436,224
5 Ventolin HFA 17,531,384
6 Advair Diskus 16,604,511
7 Diovan 13,101,107
8 Vyvanse 10,409,180
9 Spiriva Handihaler 9,594,938
10 Lantus 9,498,954
11 Lyrica 9,406,166
12 Celebrex 9,288,870
13 Lantus Solostar 9,052,819
14 Abilify 8,922,954
15 Januvia 8,745,980
16 Namenda 8,464,036
17 Nasonex 8,388,973
18 Viagra 7,751,484
19 Zetia 7,714,153
20 Suboxone 7,658,467
21 Cialis 7,469,372
22 Bystolic 6,795,951
23 Tamiflu 6,415,670
24 Flovent HFA 6,154,584
25 Oxycontin 6,005,158
26 Symbicort 5,908,888
27 Dexilant 5,196,874
28 Nuvaring 5,188,089
29 Benicar 5,018,438
30 Levemir 4,749,858
31 Premarin 4,639,414
32 Loestrin 24 FE 4,590,856
33 Proventil HFA 4,402,561
34 Afluria 4,396,084
35 Novolog 4,200,166
36 Thyroid 4,146,906
37 Voltaren Gel 4,087,123
38 Vesicare 4,035,018
39 Benicar HCT 3,961,216
40 Novolog Flexpen 3,796,220
41 Vytorin 3,733,052
42 Lunesta 3,573,075
43 Humalog 3,567,750
44 Focalin XR 3,483,905
45 Toprol-XL 3,426,000
46 Pristiq 3,414,341
47 Ortho-Tri-Cy Lo 28 3,406,933
48 Lumigan 3,265,438
49 Janumet 3,262,008
50 Travatan Z 3,099,633
51 Evista 3,037,813
52 Lo Loestrin FE 2,896,633
53 Xarelto 2,845,724
54 Avodart 2,780,336
55 Pataday 2,747,016
56 Pradaxa 2,688,081
57 Zostavax 2,577,330
58 Combivent 2,564,776
59 Seroquel XR 2,553,562
60 Strattera 2,524,961
61 Detrol LA 2,318,229
62 Trilipix 2,272,817
63 Xopenex HFA 2,249,145
64 Chantix 2,236,551
65 Humalog Kwikpen 2,234,056
66 Lipitor 2,183,138
67 Exforge 2,009,256
68 Exelon 1,893,886
69 Aciphex 1,889,412
70 Welchol 1,849,687
71 Humira 1,840,089
72 Actonel 1,833,889
73 Onglyza 1,780,339
74 Combigan 1,778,837
75 Premarin Vaginal 1,720,394
76 Diovan HCT 1,716,985
77 Victoza 3-Pak 1,684,293
78 Enbrel 1,656,421
79 Truvada 1,608,426
80 Tricor 1,593,716
81 Micardis 1,558,847
82 Azor 1,540,801
83 Alphagan P 1,537,012
84 Patanol 1,482,109
85 Norvir 1,455,910
86 Aggrenox 1,446,475
87 Effient 1,443,887
88 Ranexa 1,421,595
89 Viibryd 1,404,896
90 Dulera 1,381,074
91 Advair HFA 1,332,348
92 Prempro Low Dose 1,314,444
93 Atripla 1,289,014
94 Amitiza 1,287,691
95 Asmanex Twisthaler 1,257,602
96 Levitra 1,257,292
97 Micardis HCT 1,249,265
98 Beyaz-28 1,244,195
99 Ortho Evra 3 1,220,696
100 Humulin N 1,216,524

*New prescriptions and refills

Source: IMS National Prescription Audit, IMS Health

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