Hemangiomas in Special Anatomic Sites
Particular areas of IH involvement that may lead to functional impairment include the periocular region, airway, and liver. A systematic review focusing specifically on the use of propranolol for periocular involvement noted effectiveness in 96 of 97 patients. A meta-analysis looking at propranolol for airway hemangiomas identified 13 studies comprising 36 patients that showed propranolol to be effective in promoting resolution of airway hemangiomas; additionally, superior efficacy was demonstrated over steroids. Several case series have reported on the benefits of propranolol for the treatment of hemangiomatosis, particularly with liver involvement. One study noted improvement in 8 infants with diffuse hemangiomatosis and liver involvement. In instances where heart failure associated with hypothyroidism was also a consequence, complete resolution was noted.
Skin Therapy Letter. 2013;18(6) © 2013 SkinCareGuide.com