Treatment of Infantile Hemangiomas With Beta-Blockers

A Review

Sonal Shah, MD; Ilona J. Frieden, MD


Skin Therapy Letter. 2013;18(6) 

In This Article

Hemangiomas in Special Anatomic Sites

Particular areas of IH involvement that may lead to functional impairment include the periocular region, airway, and liver. A systematic review focusing specifically on the use of propranolol for periocular involvement noted effectiveness in 96 of 97 patients.[28] A meta-analysis looking at propranolol for airway hemangiomas identified 13 studies comprising 36 patients that showed propranolol to be effective in promoting resolution of airway hemangiomas; additionally, superior efficacy was demonstrated over steroids.[29] Several case series have reported on the benefits of propranolol for the treatment of hemangiomatosis, particularly with liver involvement. One study noted improvement in 8 infants with diffuse hemangiomatosis and liver involvement. In instances where heart failure associated with hypothyroidism was also a consequence, complete resolution was noted.[30]