Advances in Pneumococcal Antibiotic Resistance

Jae-Hoon Song


Expert Rev Resp Med. 2013;7(5):491-498. 

In This Article

Expert Commentary & Five-year View

S. pneumoniae is a major pathogen causing respiratory infections and invasive diseases in the community. Antimicrobial resistance in pneumococci has rapidly emerged worldwide since the 1990s and Asian countries have particular problems of high prevalence of pneumococcal resistance. Since the introduction of PCV7 in 2000, incidence of pneumococcal diseases has remarkably decreased with concomitant decrease in pneumococcal resistance. However, non-vaccine type pneumococci, such as serotype 19A, have rapidly emerged in many parts of the world, which are frequently associated with MDR. The increase in serotype 19A was due to the spread of drug-resistant clones worldwide. PCV13, which contains six additional serotypes including 19A, may reduce the clonal spread of multidrug-resistant serotype 19A pneumococcal strains. Changing trends in the prevalence of pneumococcal resistance and serotype distribution after PCV13 vaccination should be carefully monitored.