On Treatment but Still Sleepy

Cause and Management of Residual Sleepiness in Obstructive Sleep Apnea

Sandrine H. Launois; Renaud Tamisier; Patrick Lévy; Jean-Louis Pépin


Curr Opin Pulm Med. 2013;19(6):601-608. 

In This Article

Adverse Consequences of Residual Sleepiness

As mentioned above, EDS in residual sleepiness patients is usually moderate to severe. Surprisingly, only one study has investigated adverse consequences of residual sleepiness. EDS in OSA is predictive of increased morbidity and mortality, mainly through association with cardiovascular and metabolic disorders.[4] Yet, in a comparison of OSA patients on CPAP with and without residual sleepiness and healthy controls, residual sleepiness did not seem associated with augmented cardiovascular risk, assessed by endothelial function and inflammation biomarkers.[46] Quality of life, assessed by various questionnaires, is poor overall in residual sleepiness patients and improves with stimulant medication.[31] Intuitively, one would assume that residual sleepiness is associated with an increased risk of domestic, work or traffic accidents, but no study to date has quantified this risk.