Proteomics Strategies to Analyze HPV-Transformed Cells: Relevance to Cervical Cancer

Fabio Di Domenico; Federico De Marco; Marzia Perluigi


Expert Rev Proteomics. 2013;10(5):461-472. 

In This Article

The Need for Further Research on HPV Carcinogenesis

Although HR-HPV represent the most powerful single carcinogen for humans under natural infection conditions[19] and despite the huge amount of data has been quickly accumulated since the early proposal of their causative role in human cancer[20] several questions remain unsolved and innovative research with improved technical approaches are urgently needed.

A major unresolved question is whether HR-HPV oncogenes expression is per se sufficient to generate full neoplastic transformation or other co-carcinogenic factors are needed. Experimental data demonstrate that only a small part of cervical infections evolve to invasive cancer while the majority of them regress spontaneously. The biochemical and genetic markers of transforming HPV activity can be shown shortly after (hours/days) the beginning of viral expression. Thus HPV oncogene expression is not per se sufficient for cell transformation but additional events might be the direct long-term consequences of their expression. Answering this question will enable to set up improved markers for both diagnosis and prognostic assessment of pre-malignant lesions.[21,22]