Novel Type of Protein Chip for Multiplex Detection of Autoantibodies

Christer Wingren


Expert Rev Proteomics. 2013;10(5):417-420. 

In This Article

Five-year View

In the quest of deciphering biomarkers for disease diagnosis, prognosis and classification, high-performing multiplexed proteomic technologies, such as protein microarrays, will continue to play an increasingly central role. New biomarker signatures will be delineated providing the clinicians with unique tools and actionable information, such as earlier (and improved) diagnosis and evidence-based therapy selection. To this end, the importance of using state-of-the-art protein microarrays, based on protein probes microarray adapted by molecular design, will be absolutely essential and the benefits manifold. In the next 5 years, protein probes with in-built optimized array features are thus needed that will require novel, innovative protein designs (e.g., the introduction of non-natural amino acid derivatives to introduced completely novel properties) to be adopted, as well as design of and access to large recombinant protein libraries providing 'unlimited' access to array-designed protein probes displaying the desired biophysical properties.