The Role of Kidney in Glucose Homeostasis — SGLT2 Inhibitors, a New Approach in Diabetes Treatment

Vasileios Andrianesis; John Doupis


Expert Rev Clin Pharmacol. 2013;6(5):519-539. 

In This Article

Substrates Contribution to Renal Gluconeogenesis

Renal gluconeogenic substrates contribution to glucose release is calculated as follows: lactate 55%, glycerol 17%, glutamine 13%, alanine 4% and unknown 11%.[7] Furthermore, it is estimated that roughly half of the renal glucose release is attributed to gluconeogenesis from lactate and the half of circulating lactate converts into glucose from kidney gluconeogenic enzymes.[7] Additionally, 74% ofthe circulating glutamine and only 4% of alanine are substrates for renal gluconeogenesis.[7]