The Role of Kidney in Glucose Homeostasis — SGLT2 Inhibitors, a New Approach in Diabetes Treatment

Vasileios Andrianesis; John Doupis


Expert Rev Clin Pharmacol. 2013;6(5):519-539. 

In This Article

Hormone Regulation of Renal Gluconeogenesis

Data from human studies regarding hormonal regulation of renal gluconeogenic activity are limited to the effects of insulin, glucagon and epinephrine. Increased insulin levels have been shown to suppress renal gluconeogenesis and enhance renal medulla glucose uptake.[11,12] On the other hand, glucagon has no effect on renal glucose release and uptake.[13] Finally, the rich autonomic innervation of the kidney possibly explain the strong effect of catecholamines on renal gluconeogenesis and the prolonged renal glucose release after epinephrine infusion.[14]